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Travelers' diarrhea is a clinical syndrome that affects about 50 percent of people who travel throughout the developing world. It comes from eating contaminated food or drinking contaminated water. Travelers' diarrhea usually is caused by bacteria, but also can be caused by viruses or parasites. One of the most serious complications of travelers' diarrhea is dehydration, which in rare instances can turn into a life-threatening emergency.
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In general, travelers at risk for diarrhea commonly come from industrialized nations who travel to high-risk areas such as Latin America, Asia, Africa, and the Middle East. Men and women are at equal risk for developing travelers' diarrhea, with young people being the most commonly affected.

Travelers' diarrhea is most commonly treated with medications that provide
  • Quick but temporary relief by reducing muscle spasms in the gastrointestinal tract (Imodium)
  • A reduction in the frequency of bouts of diarrhea (Pepto-Bismol)
  • Medication that kills or inactivates bacteria in the body (antibiotics)

The TREK program is testing an investigational vaccine to determine if it prevents or lessens the symptoms of travelers' diarrhea from developing. The investigational vaccine is given via a patch on the skin.

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